We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

The comprehension of anaphoric relations may be guided not only by discourse, but also syntactic information. In the literature on online processing, however, the focus has been on audible pronouns and descriptions whose reference is resolved mainly on the former. This paper examines one relation that both lacks overt exponence, and relies almost exclusively on syntax for its resolution: adjunct control, or the dependency between the null subject of a non-finite adjunct and its antecedent in sentences such as Mickey talked (...) to Minnie before ___ eating. Using visual world eyetracking, we compare the time course of interpreting this null subject and overt pronouns (Mickey talked to Minnie before he ate). We show that when control structures are highly frequent, listeners are just as quick to resolve reference in either case. When control structures are less frequent, reference resolution based on structural information still occurs upon hearing the non-finite verb, but more slowly, especially when unaided by structural and referential predictions. This may be due to increased difficulty in recognizing that a referential dependency is necessary. These results indicate that in at least some contexts, referential expressions whose resolution depends on very different sources of information can be resolved approximately equally rapidly, and that the speed of interpretation is largely independent of whether or not the dependency is cued by an overt referring expression. (shrink)

Ritual and Myth in the International Corona-Drama. A Conversation with Jeffrey Alexander.

The following is simultaneously an essay in sociological theory, in cultural sociology, and in the empirical reconstruction of postwar Western history. Per theory, it introduces and specifies a model of cultural trauma - a model that combines a strong cultural program with concern for institutional and power effects - and applies it to large-scale collectivities over extended periods of time. Per cultural sociology, the essay demonstrates that even the most calamitous and biological of social facts - the prototypical evil of (...) genocidal mass murder - can be understood only inside of symbolic codes and narratives; that these frames change substantially depending on social circumstances; and that this culture process is critical to establishing understandings of moral responsibility. Empirically, this essay documents, in social and cultural detail, using both secondary and primary sources, how it was that the `Holocaust' gradually became the dominant symbolic representation of evil in the late twentieth century, and what its consequences have been for the development of a supra-national moral universalism that may restrict genocidal acts in the future. (shrink)

As social theorists seek to understand the contemporary challenges of radical populism, we would do well to reconsider the febrile insights of the psychoanalytic social theorist Erich Fromm. It was Fromm who, at the beginning of the 1930s, conceptualized the emotional and sociological roots of a new ‘authoritarian character’ who was meek in the face of great power above and ruthless to the powerless below. It was Fromm, in the 1950s, who argued that societies, not only individuals, could be sick. (...) This essay traces the intertwining of psychoanalytic and sociological methods that allowed Fromm to create such new ideas. At the same time, it highlights how Fromm’s sociology was hampered by an economistic Marxist approach to the institutions and culture of democratic capitalist societies. Such theoretical restriction prevented Fromm from conceptualizing how institutions like democracy, science, and psychotherapy can provide resources for widespread emotional recuperation and civil repair. (shrink)

This article examines a key question emerging from the strong program in cultural sociology — can art provide a window into social life? An examination of Giacometti's Standing Woman shows that art attempts to express cultural structures via immersion into and through the material surfaces of aesthetic form. Through an analysis of the iconic significance of family photos, furniture and celebrities, the article goes on to suggest that such iconic experience remains at the basis of contemporary social life. It explains (...) how we feel part of our surroundings, how we experience the ties that bind us to the people we know and how we develop a feeling for cultural hierarchy. (shrink)

Cultural trauma occurs when members of a collectivity feel they have been subjected to a horrendous event that leaves indelible marks upon their group consciousness, marking their memories forever and changing their future identity in fundamental and irrevocable ways. While this new scientific concept clarifies causal relationships between previously unrelated events, structures, perceptions, and actions, it also illuminates a neglected domain of social responsibility and political action. By constructing cultural traumas, social groups, national societies, and sometimes even entire civilizations, not (...) only cognitively identify the existence and source of human suffering, but may also take on board some significant moral responsibility for it. Insofar as they identify the cause of trauma in a manner that assumes such moral responsibility, members of collectivities define their solidary relationships that allow them to share the suffering of others. Is the suffering of others also our own? In thinking that it might in fact be, societies expand the circle of the ‘we’ and create the possibility for repairing societies to prevent the trauma from happening again. By the same token, social groups can, and often do, refuse to recognize the existence of others’ suffering, or place the responsibility for it on people other than themselves. Empirically, this article extensively considers trauma construction in the case of the Holocaust – the mass murder of Jews by the German Nazis – but also examines trauma processes in relation to African-Americans, indigenous peoples, colonial victims of Western and Japanese imperialism, the Nanjing Massacre, and victims of the early communist regimes in Soviet Russia and Maoist China. (shrink)

In the age of the `return to the empirical' in which the theoretical disputes of an earlier era seem to have fallen silent, we seek to excavate the intellectual conditions for reviving theoretical debate, for it is upon this recovery that deeper understanding of the nature and purpose of empirical social science depends. We argue against the all too frequent turn to ontology, whereby critical realists have sought an epistemological guarantor of sociological validity. We seek, to the contrary, to crystallize (...) a culturally-based, hermeneutic account of a rational social science. Derived from disputes within the sociology of culture, on the one hand, and the long-standing concerns of interpretive philosophy, on the other, we offer a cultural-sociological approach to epistemology. We view the production of truth in social science as a reading of a meaningful social world, and as a performance of truth-claims that is constrained by evidence, but whose success depends on other contextual factors. We conclude that the rationality of social science can be achieved only by forgoing ontology. Theories are abstractions of investigators' meanings that allow the interpretation of social meanings in turn, whether those are actions, relations, or structures. Successful explanations are those that intertwine these meaning structures of investigators and actors in an effective way. (shrink)

I make use of this reply to McLennan to offer an overall perspective on the development of my work, normatively, empirically and theoretically, and in its earlier neofunctionalist and later cultural-sociological phase. I argue that, despite periodic suggestions that my cultural sociology seeks to push sociology towards an absolute subjectivity, the social-epistemological framework of ‘multidimensionality’ around which I organized my first work, Theoretical Logic in Sociology, still holds. Cultural sociology introduces a method and theory for understanding a dimension of social (...) life, it is not an attempt to explain every part of social life. There is still structural power according to this perspective, but the nature and force of this power must be understood differently. It is a mistake for social science to take a ‘realist’ path, either in its epistemology or in its mode of explanation. (shrink)

Simmel develops his concept of the stranger in an overly structural and reductionist manner. Contrary to Simmel’s suggestion, there is an indeterminate relation between structural exclusion and the attribution of strangeness. After showing that ‘the stranger’ must be rethought in a cultural-sociological way, this essay demonstrates an alternative approach. Articulating a ‘discourse’ that structures Western projections of strangeness, I explore its relation to colonialism, racial and class domination, and national conflict in modern Western history. This approach suggests an alternative, not (...) only to Simmel but to Merton’s and Coser’s earlier structural-functional reconceptualization of stranger theory. (shrink)

The paper promotes a cultural sociological analysis of one of the most significant and hard-to-explain events in American history when the initial act of breaking and entering into the Democratic Party headquarters at the Watergate Hotel first didn't attract any substantial attention of contemporaries but later initiated a widespread political crisis. J. Alexander considers the dynamics, mechanisms and consequences of the event and its public resonance, building an explanatory model based on his cultural sociological theory. This model allows to (...) reconstruct in detail the development and maintenance of the social consensus at the different levels of cultural structures and to explain its connection to the main elements of social and political context, public rituals and performances. (shrink)

In the paper, which pretends to be a program manifesto, its authors justify a necessity of the new theoretical approach to culture which they call a “strong program” in sociology of culture. While the existing sociological approaches to culture bear a reductionist character, the “strong program” treats culture in terms of its autonomy. After a general review of the sociological conceptions of culture authors analyze the most significant approaches within the “weak program.” In the core section of the paper they (...) discuss the required steps that will make a “strong program” possible on the grounds of synthesis of structuralism and hermeneutics. (shrink)

Civil Sphere Theory provides a more dynamic, cultural, and democratically oriented model of contemporary society than either conflict or modernization theory. Civil spheres expand and contract in contradictory ways. Utopian periods of utopian repair trigger defensive efforts that primordialize and exclude. Late 20th century civil repair generated new relations of economic production and more multicultural modes of integration. Early 21rst century reactions have highlighted dangers, demanding more cultural homogeneity amidst rising concerns about inequality. There is increasing disillusionment about the possibility (...) for democratic progress. (shrink)

This essay provides an intellectual history for the cultural turn that transformed the human sciences in the mid-20th century and led to the creation of cultural sociology in the late 20th century. It does so by conceptualizing and contextualizing the limitations of the binary primitive/modernity. In the 19th and early 20th centuries, leading thinkers – among them Marx, Weber, Durkheim, and Freud – confined thinking and feeling styles like ritual, symbolism, totem, and devotional practice to a primitivism that would be (...) transformed by the rationality and universalism of modernity. While the barbarisms of the 20th century cast doubt on such predictions, only an intellectual revolution could provide the foundations for an alternative social theory. The cultural turn in philosophy, aesthetics, and anthropology erased the division between primitive and modern; in sociology, the classical writings of Durkheim were recentered around his later, religious sociology. These intellectual currents fed into a cultural sociology that challenged the sociology of culture, creating radically new research programs in the late 20th and early 21st centuries. (shrink)

This collection of original essays brings a dramatically different perspective to bear on the contemporary "crisis of journalism." Rather than seeing technological and economic change as the primary causes of current anxieties, The Crisis of Journalism Reconsidered draws attention to the role played by the cultural commitments of journalism itself. Linking these professional ethics to the democratic aspirations of the broader societies in which journalists ply their craft, it examines how the new technologies are being shaped to sustain value commitments (...) rather than undermining them. Recent technological change and the economic upheaval it has produced are coded by social meanings. It is this cultural framework that actually transforms these "objective" changes into a crisis. The book argues that cultural codes not only trigger sharp anxiety about technological and economic changes, but provide pathways to control them, so that the democratic practices of independent journalism can be sustained in new forms. (shrink)

Written in the early months of the COVID pandemic, and in the midst of the second wave of Black Lives Matters protest, this article suggests that Americans experienced these shocking social events as a double-whammy cultural trauma, as deeply troubling to their collective identity as nation. How the trauma played out would determine the near-term future of American politics. Were the poor and non-white the principal victims of the double whammy, or were white Americans and the ‘hard-working middle class’ actually (...) the injured parties? Who was the trauma’s perpetrator? Was it China, inadequate healthcare, government bureaucracy, or Trump and ‘know-nothing’ populism? The performances that provided the most felicitous answers to such questions would determine whether the country moved to the left or the right in the months before the Presidential election that would take place before year’s end. (shrink)

Avant-garde theatre is often invoked as the bellwether for a society that has become postdramatic – fragmented, alienated, and critical of efforts to create collectively shared meanings. A theatre whose sequenced actions have no narrative (so the story goes) mirrors a social world where the most conflictual situations no longer appear as drama but merely as spectacle: a society where audiences look on without any feeling or connection. Because only half right, these theses about postdramatic theatre and society are fundamentally (...) wrong. As modern societies have expanded and differentiated, the elements that compose performances have become separated and often fragmented in both theatre and society. If they can be brought back together again, performances are viewed as authentic and meaningful. If (re)fusion cannot be achieved, performances fail to communicate meaning. The aim of this essay is to demonstrate that a shared ambition to (re)fuse fragmented performative elements has defined the most important strain of avant-garde theatre over the last two centuries. Most radical theatrical innovation has sought to open live drama back up to the telos of myth and ritual. Neither in theatre nor social life can the world transcend dramaturgy; it is fundamental to the search for meaning in a world beyond cosmological religion. (shrink)

Sentences such as “The ship was sunk to collect the insurance” exhibit an unusual form of anaphora, implicit control, where neither anaphor nor antecedent is audible. The non-finite reason clause has an understood subject, PRO, that is anaphoric; here it may be understood as naming the agent of the event of the host clause. Yet since the host is a short passive, this agent is realized by no audible dependent. The putative antecedent to PRO is therefore implicit, which it normally (...) cannot be. What sorts of representations subserve the comprehension of this dependency? Here we present four self-paced reading time studies directed at this question. Previous work showed no processing cost for implicit vs. explicit control, and took this to support the view that PRO is linked syntactically to a silent argument in the passive. We challenge this conclusion by reporting that we also find no processing cost for remote implicit control, as in: “The ship was sunk. The reason was to collect the insurance.” Here the dependency crosses two independent sentences, and so cannot, we argue, be mediated by syntax. Our Experiments 1–4 examined the processing of both implicit (short passive) and explicit (active or long passive) control in both local and remote configurations. Experiments 3 and 4 added either “3 days ago” or “just in order” to the local conditions, to control for the distance between the passive and infinitival verbs, and for the predictability of the reason clause, respectively. We replicate the finding that implicit control does not impose an additional processing cost. But critically we show that remote control does not impose a processing cost either. Reading times at the reason clause were never slower when control was remote. In fact they were always faster. Thus, efficient processing of local implicit control cannot show that implicit control is mediated by syntax; nor, in turn, that there is a silent but grammatically active argument in passives. (shrink)

Background and Aims Progress towards validating amyloid beta as an early indicator of Alzheimer’s disease (AD) heightens the need for evaluation of stakeholders’ perspectives of the benefits and harms of preclinical testing in asymptomatic individuals. Methods Investigators conducted and analyzed 14 semi-structured interviews with family members of patients diagnosed with AD. Results Participants reported benefits, including the potential to seek treatment, make lifestyle changes, and prepare for cognitive impairment. Participants identified harms, including social harms, adverse life decisions, and psychological harms. (...) Nine participants reported either a “positive global perspective” or a “positive global perspective (qualified).” Conclusion Results from this study characterized stakeholders’ perspectives on the potential benefits and harms of clinical use of preclinical testing for AD. Investigators used data from this study to develop a framework that contributes to ongoing discussions that will evaluate widespread adoption of preclinical testing and will inform future research. (shrink)

This four-volume set presents an unrivalled collection of the key literature in European sociology. The prestigious texts range across the European tradition from enlightenment to contemporary theory. The collection explodes the myth that the European tradition in sociology is a debate with the ghosts of Karl Marx and Max Weber, demonstrating that the tradition is far more deeply rooted and broadly based. Volume 1 is devoted to the emergence of European sociology. The contribution of classical political economy and the Enlightenment (...) is examined. Commentaries on the work of Hobbes, Locke, Montesquieu, Taine, Rousseau, de Tocqueville, Comte and St. Simon are included. The volume creates a vivid and compelling picture of the origins of European sociology. Volume 2 covers the rise of the classical period in social theory. It includes commentaries on the contribution of Marx, Spencer, Dilthey, Weber, Durkheim and Simmel. An overview of the main contributions of the founding fathers is also included. Volume 3 moves on to explore the main developments in the first half of the twentieth century. The contributions of the Durkheimian Tradition, Mauss, Mannheim, Lukacs, Gramsci and British sociology are presented. The volume provides a synoptic view of the diversity and emerging complexity of European sociology. Volume 4 identifies the main developments from post-industrial theory to the present day. The volume includes commentaries on the work of Aron, Foucault, Habermas, Giddens, Bourdieu, Boudon and Gellner. Selections on structuralism, polysemy, the positivist dispute and the neo-liberal tradition widen out the picture. The collection is the benchmark work for understanding the history, contribution and dilemmas of the European tradition. Full account is taken of the reference needs of students as well as of academics. Each hardcover volume of 416 pages is bound to the highest standards. The lettering on the cover is gold embossed. The slip case for the four volumes is also embossed. The volumes are not available separately. (shrink)

Host-microbiome interactions (HMIs) are critical for the modulation of biological processes and are associated with several diseases, and extensive HMI studies have generated large amounts of data. We propose that the logical representation of the knowledge derived from these data and the standardized representation of experimental variables and processes can foster integration of data and reproducibility of experiments and thereby further HMI knowledge discovery. A community-based Ontology of Host-Microbiome Interactions (OHMI) was developed following the OBO Foundry principles. OHMI leverages established (...) ontologies to create logically structured representations of microbiomes, microbial taxonomy, host species, host anatomical entities, and HMIs under different conditions and associated study protocols and types of data analysis and experimental results. (shrink)

Quantificational determiners are often said to be devices for expressing relations. For example, the meaning of _every_ is standardly described as the inclusion relation, with a sentence like _every frog is green_ meaning roughly that the green things include the frogs. Here, we consider an older, non-relational alternative: determiners are tools for creating restricted quantifiers. On this view, determiners specify how many elements of a restricted domain (e.g., the frogs) satisfy a given condition (e.g., being green). One important difference concerns (...) how the determiner treats its two grammatical arguments. On the relational view, the arguments are on a logical par as independent terms that specify the two relata. But on the restricted view, the arguments play distinct logical roles: specifying the limited domain versus supplying an additional condition on domain entities. We present psycholinguistic evidence suggesting that the restricted view better describes what speakers know when they know the meaning of a determiner. In particular, we find that when asked to evaluate sentences of the form _every F is G_, participants mentally group the Fs but not the Gs. Moreover, participants forego representing the group defined by the intersection of F and G. This tells against the idea that speakers understand _every F is G_ as implying that the Fs bear relation (e.g., inclusion) to a second group. (shrink)

Jeffrey conditionalization is a rule for updating degrees of belief in light of uncertain evidence. It is usually assumed that the partitions involved in Jeffrey conditionalization are finite and only contain positive-credence elements. But there are interesting examples, involving continuous quantities, in which this is not the case. Q1 Can Jeffrey conditionalization be generalized to accommodate continuous cases? Meanwhile, several authors, such as Kenny Easwaran and Michael Rescorla, have been interested in Kolmogorov’s theory of regular conditional distributions (...) as a possible framework for conditional probability which handles probability-zero events. However the theory faces a major shortcoming: it seems messy and ad hoc. Q2 Is there some axiomatic theory which would justify and constrain the use of rcds, thus serving as a possible foundation for conditional probability? These two questions appear unrelated, but they are not, and this paper answers both. We show that when one appropriately generalizes Jeffrey conditionalization as in Q1, one obtains a framework which necessitates the use of rcds. It is then a short step to develop a general theory which addresses Q2, which we call the theory of extensions. The theory is a formal model of conditioning which recovers Bayesian conditionalization, Jeffrey conditionalization, and conditionalization via rcds as special cases. (shrink)

The differences between the theories of hearing held by Aristotle and by Alexander of Aphrodisias are explored. Alexander appears to have a more systematic approach which avoids the dilemma faced by Aristotle in deciding whether the hearing process constitutes a time-taking kinesis or an instantaneous energeia.

This Editorial reports an exchange in form of a comment and reply on the article “History and Nature of the Jeffreys–Lindley Paradox” (Arch Hist Exact Sci 77:25, 2023) by Eric-Jan Wagenmakers and Alexander Ly.

Timeless advice on how to be a successful leader in any field The ancient biographer and essayist Plutarch thought deeply about the leadership qualities of the eminent Greeks and Romans he profiled in his famous—and massive—Lives, including politicians and generals such as Pericles, Alexander the Great, Julius Caesar, and Mark Antony. Luckily for us, Plutarch distilled what he learned about wise leadership in a handful of essays, which are filled with essential lessons for experienced and aspiring leaders in any (...) field today. In How to Be a Leader, Jeffrey Beneker presents the most important of these essays in lively new translations accompanied by an enlightening introduction, informative notes, and the original Greek on facing pages. In "To an Uneducated Leader," "How to Be a Good Leader," and "Should an Old Man Engage in Politics?" Plutarch explains the characteristics of successful leaders, from being guided by reason and exercising self-control to being free from envy and the love of power, illustrating his points with memorable examples drawn from legendary Greco-Roman lives. He also explains how to train for leadership, persuade and deal with colleagues, manage one's career, and much more. Writing at the height of the Roman Empire, Plutarch suggested that people should pursue positions of leadership only if they are motivated by "judgment and reason"—not "rashly inspired by the vain pursuit of glory, a sense of rivalry, or a lack of other meaningful activities." His wise counsel remains as relevant as ever. (shrink)

The phenomenon of altruism extends from the biological realm to the human sociocultural realm. This article sketches a coherent outline of multiple types of altruism of progressively increasing scope that span these two realms and are grounded in an ever-expanding sense of “self.” Discussion of this framework notes difficulties associated with altruism at different levels. It links scientific ideas about the evolution of cooperation and about hierarchical order to perennial philosophical and religious concerns. It offers a conceptual background for inquiry (...) into societal challenges that call for altruistic behavior, especially the challenge of environmental and social sustainability. (shrink)

Aristotle (384-322 BC) was an ancient Greek philosopher, pupil of Plato, and tutor of Alexander the Great. His works span the topics of biology, metaphysics, mind, logic, language, science, epistemology, ethics, and politics. Aristotle held that there are many divine beings, but a supremely divine being is the first cause of the universe and the goodness of all other beings. This divine being plays a fundamental explanatory role in Aristotle’s thought.

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 63.4 (2002) 659-676 [Access article in PDF] Adam Smith's "Letter to the Authors of the Edinburgh Review" Jeffrey Lomonaco One of Adam Smith's first publications was a letter addressed to the editors of the Edinburgh Review, printed anonymously in the second issue of the semiannual periodical in 1756. 1 The compact text entitled "A LETTER to the Authors of the Edinburgh Review," (...) which has received surprisingly little scholarly attention, offers valuable insight into Smith's work and career, and not merely because it confirms that Smith was an unusually widely-read man of letters long before he was the retrospectively anointed founder of the discipline of economics, though it does that. Indeed, the thirty-two-year-old writer presumes to pass judgment on the writing and learning of Europe as a whole and specifically assesses the only recently published work of Rousseau, the Encyclopédie project still in progress, and the work of Réaumur, Buffon and Daubenton, Descartes, Newton, and others. In this text (whose authorship was known well before Dugald Stewart noted it in his biographical account in the early 1790s) Smith delineates a space of learning that is at once Scottish, British, and European, mapping out a set of relations of complex rivalry between France, England, and Scotland in order to articulate and advocate a cosmopolitan patriotism. 2 He suggests that while England occupied the preeminent position in learning in the past, France does so in the present, and Scotland is in a position to do so in the near future, if it is properly incited. Smith's careful [End Page 659] rhetorical incitement of his Scottish contemporaries to fulfill this promise of future primacy in learning also reveals his own ambitions and how he proposed to realize them.My reading of the text will throw into relief Smith's strategy and show how, although Smith does not name his good friend David Hume, he subtly expresses his own allegiances to the Humean science of man as the way for Scotland to achieve primacy in the world of learning, and he indicates that the most important task facing the world of knowledge—the task he takes as his own—concerns the proper systematic organization and presentation of moral knowledge. That Smith's is a subtle writerly performance which calls for attention to the grain of the text is itself part of the point of my interpretation, especially since the rhetorical care Smith took in composition is generally underestimated, or at least not adequately attended to in detail. 3 Judging Rivals The Edinburgh Review was a project begun by a number of members of the Select Society, one of those social vehicles of improvement and enlightenment that flourished throughout Europe in the eighteenth century. 4 Smith was a founding member of the Select Society in 1754 and may have been one of the initiators of the periodical, to the inaugural 1755 issue of which he contributed a review of Johnson's Dictionary. 5 The preface of the opening issue of the Review, probably written by the editor Alexander Wedderburn, a close friend of Smith's, positioned the Review as Scotland's somewhat belated contribution to the widespread European print enterprise of bringing advances in knowledge to the attention of the public. 6 The purpose of the periodical, Wedderburn's preface declared, was to demonstrate "the progressive state of learning in this country" and thereby to incite Scots "to a more eager pursuit of learning, to [End Page 660] distinguish themselves, and to do honour to their country." 7 To these ends each issue of the Review was going "to give a full account of all books published in Scotland within the compass of half a year; and to take some notice of such books published elsewhere, as are most read in this country, or seem to have any title to draw the public attention." 8 The title page of the first issue, which appeared on 26 August 1755 and which covered books published between 1 January and... (shrink)

Abstract:This study links Homeric and Machiavellian outlooks in Henry James's The Ambassadors. We first relate Lambert Strether's embassy seeking Chad's return to Woollett to what Alexander Pope famously designated the "Embassy to Achilles," i.e., the Achaean effort to induce Achilles's return to battle. Achilles impassionedly rejects the embassy's hypocrisy; he will not be bought. We then find Chad Newsome conspiratorially excluding Strether from the family fortune via intended marriage to Mrs. Newsome. Contrary to Achilles's forthrightness and integrity, Chad and (...) his Parisian circle adopt a post-Machiavellian ethos of deceit as the norm. (shrink)

It is widely known that one of the projects that was most preoccupying the late, and much regretted, Alexander Kazhdan in his latter years was a study of Byzantine literature that would bring this field into the modern era. For far too long Byzantine literature, he asserted, had been encased in the strait-jacket imposed by Krumbacher's magisterial Geschichte. Byzantinists were constrained by a Handbuch mentality whose bonds had been confirmed by the three volumes that replaced Krumbacher's single tome: Beck (...) on ‘Theologische Literatur’ and ‘Volksliteratur’ and Hunger on high-style secular literature. However humane the tone might appear at times in these reference works (Hunger's contributions being particularly noteworthy), nothing could disguise the fact that these books were taxonomic catalogues. Byzantium's literary output was categorised by genre, genres largely imposed by modern historians and not necessarily recognisable to any Byzantine: authors were disposed under a series of at times arbitrary divisions and it was virtually impossible to have a sense of any individual's total output; Psellos was perhaps the most notoriously splintered example. Furthermore, the content of these catalogues was resolutely pragmatic: names, dates, works, editions, contents. Qualitative assessments were eschewed, there was little interpretation of literary movements. (shrink)

The Jeffreys–Lindley paradox exposes a rift between Bayesian and frequentist hypothesis testing that strikes at the heart of statistical inference. Contrary to what most current literature suggests, the paradox was central to the Bayesian testing methodology developed by Sir Harold Jeffreys in the late 1930s. Jeffreys showed that the evidence for a point-null hypothesis $${\mathcal {H}}_0$$ H 0 scales with $$\sqrt{n}$$ n and repeatedly argued that it would, therefore, be mistaken to set a threshold for rejecting $${\mathcal {H}}_0$$ H 0 (...) at a constant multiple of the standard error. Here, we summarize Jeffreys’s early work on the paradox and clarify his reasons for including the $$\sqrt{n}$$ n term. The prior distribution is seen to play a crucial role; by implicitly correcting for selection, small parameter values are identified as relatively surprising under $${\mathcal {H}}_1$$ H 1. We highlight the general nature of the paradox by presenting both a fully frequentist and a fully Bayesian version. We also demonstrate that the paradox does not depend on assigning prior mass to a point hypothesis, as is commonly believed. (shrink)

Certain hypotheses cannot be directly confirmed for theoretical, practical, or moral reasons. For some of these hypotheses, however, there might be a workaround: confirmation based on analogical reasoning. In this paper we take up Dardashti, Hartmann, Thébault, and Winsberg’s (in press) idea of analyzing confirmation based on analogical inference Baysian style. We identify three types of confirmation by analogy and show that Dardashti et al.’s approach can cover two of them. We then highlight possible problems with their model as a (...) general approach to analogical inference and argue that these problems can be avoided by supplementing Bayesian update with Jeffrey conditionalization. (shrink)

John Rawls’ Difference Principle, which requires that primary goods--income, wealth, and opportunities--be distributed so as to maximize the primary goods of the least advantaged class, has both a libertarian and a welfarist interpretation. The welfarist interpretation, which fits somewhat more easily with Rawls’ method for deriving principles of justice--rational contractors choosing principles behind the veil of ignorance--and with Rawls’ contention that there is a natural affirmative duty to aid others and to help establish and maintain just institutions, is the orthodox (...) interpretation. But there is scattered, fragmentary evidence for the libertarian interpretation as well. In this article I examine a recent version of the libertarian interpretation put forward by Jeffrey Reiman and discuss its implications as a standard for justice in cooperative arrangements. (shrink)

John Rawls’ Difference Principle, which requires that primary goods--income, wealth, and opportunities--be distributed so as to maximize the primary goods of the least advantaged class, has both a libertarian and a welfarist interpretation. The welfarist interpretation, which fits somewhat more easily with Rawls’ method for deriving principles of justice--rational contractors choosing principles behind the veil of ignorance--and with Rawls’ contention that there is a natural affirmative duty to aid others and to help establish and maintain just institutions, is the orthodox (...) interpretation. But there is scattered, fragmentary evidence for the libertarian interpretation as well. In this article I examine a recent version of the libertarian interpretation put forward by Jeffrey Reiman and discuss its implications as a standard for justice in cooperative arrangements. (shrink)

A model of the neuropsychology of anxiety is proposed. The model is based in the first instance upon an analysis of the behavioural effects of the antianxiety drugs in animals. From such psychopharmacologi-cal experiments the concept of a “behavioural inhibition system” has been developed. This system responds to novel stimuli or to those associated with punishment or nonreward by inhibiting ongoing behaviour and increasing arousal and attention to the environment. It is activity in the BIS that constitutes anxiety and that (...) is reduced by antianxiety drugs. The effects of the antianxiety drugs in the brain also suggest hypotheses concerning the neural substrate of anxiety. Although the benzodiazepines and barbiturates facilitate the effects of γ-aminobutyrate, this is insufficient to explain their highly specific behavioural effects. Because of similarities between the behavioural effects of certain lesions and those of the antianxiety drugs, it is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system, the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergic pathways which innervate these forebrain structures. Analysis of the functions of this system suggests that it acts as a comparator: it compares predicted to actual sensory events and activates the outputs of the BIS when there is a mismatch or when the predicted event is aversive. Suggestions are made as to the functions of particular pathways within this overall brain system. The resulting theory is applied to the symptoms and treatment of anxiety in man, its relations to depression, and the personality of individuals who are susceptible to anxiety or depression. (shrink)

In C. S. Peirce, as well as in the work of many biosemioticians, the semiotic object is sometimes described as a physical “object” with material properties and sometimes described as an “ideal object” or mental representation. I argue that to the extent that we can avoid these types of characterizations we will have a more scientific definition of sign use and will be able to better integrate the various fields that interact with biosemiotics. In an effort to end Cartesian dualism (...) in semiotics, which has been the main obstacle to a scientific biosemiotics, I present an argument that the “semiotic object” is always ultimately the objective of self-affirmation (of habits, physical or mental) and/or self-preservation. Therefore, I propose a new model for the sign triad: response-sign-objective. With this new model it is clear, as I will show, that self-mistaking (not self-negation as others have proposed) makes learning, creativity and purposeful action possible via signs. I define an “interpretation” as a response to something as if it were a sign, but whose semiotic objective does not, in fact, exist. If the response-as-interpretation turns out to be beneficial for the system after all, there is biopoiesis. When the response is not “interpretive,” but self-confirming in the usual way, there is biosemiosis. While the conditions conducive to fruitful misinterpretation (e.g., accidental similarity of non-signs to signs and/or contiguity of non-signs to self-sustaining processes) might be artificially enhanced, according to this theory, the outcomes would be, by nature, more or less uncontrollable and unpredictable. Nevertheless, biosemiotics could be instrumental in the manipulation and/or artificial creation of purposeful systems insofar as it can describe a formula for the conditions under which new objectives and novel purposeful behavior may emerge, however unpredictably. (shrink)

Drawing on previous models of anxiety, intermediate memory, the positive symptoms of schizophrenia, and goal-directed behaviour, a neuropsychological hypothesis is proposed for the generation of the contents of consciousness. It is suggested that these correspond to the outputs of a comparator that, on a moment-by-moment basis, compares the current state of the organism's perceptual world with a predicted state. An outline is given of the information-processing functions of the comparator system and of the neural systems which mediate them. The hypothesis (...) appears to be able to account for a number of key features of the contents of consciousness. However, it is argued that neitherthis nor any existing comparable hypothesis is yet able to explain why the brain should generate conscious experience of any kind at all. (shrink)